Function switching with fast asynchronous acquisition

摘要

A method of analyzing a sample is disclosed comprising transmitting a first population of ions through a mass spectrometer and switching a state or mode of the mass spectrometer to produce a second population of ions. A sequential stream of mass spectra is acquired asynchronously with respect to switching the state or mode of the mass spectrometer. The stream of mass spectral data is then post-processed to produce mass spectra corresponding predominantly to the first and second population of ions.

主权项

1. A method of analysing a sample comprising:
operating a mass spectrometer in a state or mode wherein first ions are analysed; switching a state or mode of said mass spectrometer so that second ions are analysed, wherein said step of switching a state or mode of said mass spectrometer comprises switching or altering an operational parameter of said mass spectrometer; acquiring a stream of mass spectral data wherein the acquisition of said mass spectral data is substantially asynchronous with or is not synchronised with the switching of said mass spectrometer between states or modes; and post-processing said stream of mass spectral data to produce: (i) mass spectral data relating to said first ions; or (ii) mass spectral data relating to said second ions.