Dual cation dual anion coordination complexes

摘要

Compounds are provided herein which are coordination complexes of the formula, AxByCit2Fz.mH2O, wherein A is a cation selected from certain IA or IIA metal ions in the Periodic Table; B is a cation selected from certain IIA metal ions and certain divalent d-block transition metal ions; A and B are different; “Cit” is tribasic citric acid anion; the stoichiometric ratio of x to y is equal or higher than 1.0 but lower than 8.0; m is 0-12; and z is selected such that electroneutrality is preserved. Compounds provided herein are useful to treat dietary deficiencies, osteoporosis, osteopenia, bone loss, and risk of bone loss, as well as other medical conditions involving the need for administration of the various ions. In addition, the compounds can be used as fluoride sources for dental use and to fluoridate water systems.

主权项

1. A compound of the formula: AxByCit2Fz, wherein:
A is a cation selected from the group consisting of the Periodic Table IA metal ions lithium (Li), sodium (Na), and potassium (K) and the Periodic Table IIA metal ions Magnesium (Mg) and Calcium (Ca); B is a cation selected from the Periodic Table IIA metal ions Magnesium (Mg) and Calcium (Ca), and the Periodic Table divalent d-block transition metal ions Copper (Cu) and Zinc (Zn); A and B are different; “Cit” is tribasic citric acid anion; the ratio of x to y is equal or higher than 1.0 but lower than 8.0; z is selected such that electroneutrality is preserved; and wherein z is adjusted so that when A and B are both selected from ions having a valence of plus 2, 2x+2y is equal to z+6; or wherein z is adjusted so that when A is selected from ions having a valence of plus 1 and B is selected from ions having a valence of plus 2, x+2y is equal to z+6; and wherein said compound comprises fluoride.