| 发明名称 | Bioactive hydrogel | ||
| 摘要 | The invention relates to a bioactive hydrogel as a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound directly by reaction of the carboxyl groups activated with 1-ethyl-3-(3-dimethylaminopropyl) carbodiimides/N-hydroxysulfosuccinimide (EDC/s-NHS) with the terminal amino groups of the polyethylene glycol covalently by amide bonds. | ||
| 申请公布号 | US8859706(B2) | 申请公布日期 | 2014.10.14 |
| 申请号 | US200813131295 | 申请日期 | 2008.11.28 |
| 申请人 | Zetascience GmbH | 发明人 | Werner Carsten;Freudenberg Uwe;Meinhold Dorit;Gouzy Marie-Francoise;Welzel Petra |
| 分类号 | A61L33/08;A61L33/10;A61L33/12;A61K38/18;A61K47/42;A61K47/36;C08B37/10;C08J5/18;C08J3/075;C08B37/00;C08L5/10;A61L27/54;A61L27/52;C08J3/24 | 主分类号 | A61L33/08 |
| 代理机构 | Servilla Whitney LLC | 代理人 | Servilla Whitney LLC |
| 主权项 | 1. A bioactive hydrogel comprising a hybrid material of heparin and star-branched polyethylene glycol with functionalized end groups, wherein the heparin is bound covalently to the polyethylene glycol via enzyme-cleavable peptide sequences as cros slinking molecules. | ||
| 地址 | Dresden DE | ||