Thiophene inhibitors of S-nitrosoglutathione reductase

摘要

The present invention is directed to novel thiophene inhibitors of S-nitrosoglutathione reductase (GSNOR), pharmaceutical compositions comprising such GSNOR inhibitors, and methods of making and using the same.

主权项

1. A method of treatment of pulmonary disorders comprising administering a therapeutically effective amount of a compound Formula I or a pharmaceutically acceptable salt thereof: wherein: X and Y are selected from the group consisting of S or CH, provided that when X is S, Y must be CH and when X is CH, Y must be S; Ar is selected from the group consisting of phenyl and thiophen-yl; R1 is selected from the group consisting of hydrogen, unsubstituted imidazolyl, substituted imidazolyl, carbamoyl, chloro, bromo, fluoro, hydroxy, and methoxy; R2 is selected from the group consisting of hydrogen, methyl, chloro, fluoro, hydroxy, methoxy, ethoxy, propoxy, carbamoyl, dimethylamino, amino, formamido, and trifluoromethyl; R3 is selected from the group consisting of hydrogen, methyl, methoxy, chloro, and fluoro; and R4 is selected from the group consisting of CONH2, NHSO2CH3, hydroxy, chloro, and substituted and unsubstituted imidazolyl.