Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid

摘要

Process for the synthesis of the compound of formula (I):;
Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.

主权项

1. A process for the synthesis of a compound of formula (I):wherein a compound of formula (VII):is subjected to the action of 1-(isocyanomethylsulphonyl)-4-methylbenzene (TosMIC) in the presence of a base in an organic solvent to yield the compound of formula (I).