| 主权项 |
1. A compound having the formula: or a physiologically acceptable salt thereof, wherein: R1 is a heteroaryl optionally substituted with 1, 2 or 3 R4 groups; R2 is hydrogen, alkoxy, heterocyclylalkyl, heterocyclylalkoxy or R3; each occurrence of R3 is independently—Y—SOq—Z or —Y—N(R5)—SOq—Z;
each occurrence of X is independently —C(R5)— or —N—; each occurrence of Y is independently a bond, alkoxy, alkoxyalkoxy or arylalkoxy; each occurrence of Z is independently alkyl, —N(R6)(R6′), or -heterocyclylalkyl optionally substituted with 1, 2 or 3 R4 groups; each occurrence of R4 may be the same or different and is independently amino, halogen, amino, alkylamino, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalklyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, heterocyclyl or heterocyclylalkyl; each occurrence of R5 is independently hydrogen or alkyl; each occurrence of R6 and R6′ may be the same or different and is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalklyl, cycloalkenyl, aryl, arylalkyl, heteroaryl, heterocyclyl, or heterocyclylalkyl, wherein R6 and R6′ may be attached to each other to form a heterocyclic ring through a bond or through one or more O, C, N, S, SOq or carbonyl, and wherein at least one N is part of the heterocyclic ring; and each occurrence of n is independently an integer from 1-4; and each occurrence of p is independently an integer from 0-2. |
