Inclusion complex of deoxypodophyllotoxin of cyclodextrin, preparation method, use for treatment of cancer thereof

摘要

Inclusion complex of deoxypodophyllotoxin of cyclodextrin, the preparation method and the use for the treatment of cancer thereof are disclosed. The inclusion complex consists of deoxypodophyllotoxin and beta-cyclodextrin derivative, wherein the molar ration of deoxypodophyllotoxin to beta-cyclodextrin derivative is 1:1-1:10. The beta-cyclodextrin derivative is sulfobutyl ether-beta-cyclodextrin or hydroxypropyl-beta-cyclodextrin.

主权项

1. An inclusion complex of deoxypodophyllotoxin and β-cyclodextrin derivative, wherein the molar ratio of deoxypodophyllotoxin to β-cyclodextrin derivative is from 1:1.00 to 1:8.06, wherein the β-cyclodextrin derivative is sulfobutyl ether-β-cyclodextrin or hydroxypropyl β-cyclodextrin.