Electron beam sculpting of tunneling junction for nanopore DNA sequencing

摘要

A technique for a nanodevice is provided that includes a reservoir filled with a conductive fluid and a membrane separating the reservoir. The membrane includes an electrode layer having a tunneling junction formed therein. A nanopore is formed through the membrane, and the nanopore is formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer. When a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a signature for distinguishing the base. When an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base.

主权项

1. A method of configuring a nanodevice, the method comprising:
filing a reservoir with a conductive fluid; configuring a membrane to separate the reservoir in the nanodevice, the membrane comprising an electrode layer having a tunneling junction formed therein; and configuring the membrane to have a nanopore formed through other layers of the membrane such that the nanopore is aligned with the tunneling junction of the electrode layer; wherein when a voltage is applied to the electrode layer, a tunneling current is generated by a base in the tunneling junction to be measured as a current signature for distinguishing the base; wherein when an organic coating is formed on an inside surface of the tunneling junction, transient bonds are formed between the electrode layer and the base; and wherein the organic coating includes a selection from hydroxamic acid, resorcinol functionality, adnine monophosphonic acid, guanine monophosphonic acid, sulfonamides, and sulfonic acid.