Process for production of ketomalonic acid compounds or hydrates thereof

摘要

Disclosed is a process for the production of ketomalonic acid compounds or hydrates thereof by reacting a malonic acid compound with one or more chlorous acid compounds selected from among chlorous acid and chlorites and thus oxidizing the methylene group of the malonic acid compound. The process does not necessitate highly toxic reagents, lowly safe reagents, special reactants, special reaction equipment, expensive reagents, expensive catalysts, or transition metals such as noble metals, and permits the selection of mild reaction conditions and simple operation, thus enabling efficient and easy production of ketomalonic acid compounds such as ketomalonic diesters under simple and easy conditions suitable for industrialization.

主权项

1. A method of producing a ketomalonic acid compound represented by following general formula (2): (wherein R1 may be the same or different from each other and represents a hydrogen atom, an alkyl group which may be substituted with, a cyclic alkyl group which may be substituted with, an aromatic hydrocarbon group which may have a substituent, or an aromatic heterocyclic group which may have a substituent, and the two R1s may bind to each other to form a cyclic structure as a whole molecule) or a hydrate thereof, by reacting a malonic acid compound represented by following general formula (1): (wherein R1 is the same as described above) or a mixture thereof, with one or two or more chlorous acid compounds selected from a chlorous acid or a salt of chlorous acid, to oxidize the malonic acid compound.