Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors

摘要

The present invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor with anti-cancer activity. More particularly, this invention relates to an indirubin-3′-oxime derivative as potent cyclin dependent kinase inhibitor having excellent anti-cancer activity against human lung cancer cell, human fibro sarcoma cell, human colon cancer cell, human leukemia cell, human stomach cancer cell, human nasopharyngeal cancer cell and/or human breast cancer cell.

主权项

1. An indirubin-3′-oxime derivative compound as cyclin dependent kinase inhibitor represented by formula (I) wherein i) R1 is OH and R2 is NO2; ii) R1 is F and R2 is NO2; iii) R1 is OH and R2 is Cl; or iv) R1 is OH and R2 is F.