| 发明名称 | Polymorphs of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, and preparation thereof and use thereof | ||
| 摘要 | Disclosed are a polymorphs I-VI of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine or of a solvate thereof, a preparation method thereof, and a use thereof as a biological active ingredient. The polymorphs are useful in treatment of cancers, and diseases or disorders caused by abnormal cell proliferation. | ||
| 申请公布号 | US8859594(B2) | 申请公布日期 | 2014.10.14 |
| 申请号 | US201113881706 | 申请日期 | 2011.10.25 |
| 申请人 | Tianjin Hemay Bio-Tech Co., Ltd.;Tianjin Michele Sci-Tech Development Co., Ltd. | 发明人 | Zhang Hesheng;Chen Xin |
| 分类号 | C07D213/75;C07D213/74;A61K31/4409;A61P35/00 | 主分类号 | C07D213/75 |
| 代理机构 | Kilpatrick Townsend & Stockon LLP | 代理人 | Kilpatrick Townsend & Stockon LLP |
| 主权项 | 1. A polymorph of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine, characterized in that the X-ray powder diffraction pattern of the polymorph of N-(6-(4-chlorophenoxy)hexyl)-N′-cyano-N″-(4-pyridyl)guanidine has the following peaks:Diffraction anglesIntensityDiffraction anglesIntensity(2θ, °)(I/I0)(2θ, °)(I/I0)14.34026.515.82116.316.75915.918.040100.020.20150.120.92134.321.42157.323.78158.724.13916.624.66057.926.26016.126.48420.2. | ||
| 地址 | Tianjin CN | ||