| 发明名称 |
Compound for inhibiting type 5 phosphodiesterase and preparation method thereof |
| 摘要 |
The present invention discloses a compound of formula (I) and citrate thereof as type 5 phosphodiesterase inhibitor, a preparation method thereof, and a pharmaceutical composition including the compound of formula (I) and citrate thereof. The experimental results of the present invention prove that the compound of formula (I) and citrate thereof can inhibit activity of type 5 phosphodiesterase, and can be used for treating erectile dysfunction, inhibiting platelet aggregation and treating thrombosis, decreasing pulmonary hypertension and treating cardiovascular diseases, treating asthma and treating diabetes gastroparesis. |
| 申请公布号 |
US8859565(B2) |
申请公布日期 |
2014.10.14 |
| 申请号 |
US201013512524 |
申请日期 |
2010.07.30 |
| 申请人 |
|
发明人 |
Zhang Nan;Zhong Rong |
| 分类号 |
A01N43/90;A61K31/519;C07D487/00;C07D487/04;C07C59/265 |
主分类号 |
A01N43/90 |
| 代理机构 |
Pauly, Devries Smith & Deffner, LLC |
代理人 |
Pauly, Devries Smith & Deffner, LLC |
| 主权项 |
1. A compound 5-1-methyl-3-propyl-1,6-dihydro-7H-pyrazolo pyrimidine-7-ketone citrate as represented by formula II: |
| 地址 |
|
