| 发明名称 | Adjuvant or pharmaceutical preparation for transdermal or transmucosal administration | ||
| 摘要 | An adjuvant for transdermal or transmucosal administration which comprises at least one substance selected from an aliphatic alcohol, a free fatty acid and a fatty acid derivative but does not contain a substance represented by the following formula: wherein R3 and R4 may together form a cyclic ring, and R1 and R2 independently represent an alkyl side chain having 1 to 16 carbon atoms.; | ||
| 申请公布号 | US8858962(B2) | 申请公布日期 | 2014.10.14 |
| 申请号 | US201213367679 | 申请日期 | 2012.02.07 |
| 申请人 | Hisamitsu Pharmaceutical Co., Inc. | 发明人 | Tokumoto Seiji;Adachi Hirotoshi;Kuwahara Tetsuji |
| 分类号 | A61K9/00;A61K39/39;A61K47/26;A61K39/00;A61K47/34;A61K47/10;A61K47/12 | 主分类号 | A61K9/00 |
| 代理机构 | Licata & Tyrrell P.C. | 代理人 | Licata & Tyrrell P.C. |
| 主权项 | 1. A method for enhancing immunogenicity of a vaccine, said method comprising transdermally applying to skin an immunostimulatory adjuvant comprising at least one free fatty acid, and optionally at least one aliphatic alcohol, and administering the vaccine by oral, injection, transmucosal or transdermal administration, wherein at least one of the aliphatic alcohols is a saturated or unsaturated straight-chain or branched alcohol having 12 to 20 carbons, and wherein at least one of the free fatty acid is oleic acid so that immunogenicity of the vaccine is enhanced. | ||
| 地址 | Saga JP | ||