Liquid dispensing for high-throughput experimentation

摘要

Methods, systems, and apparatus, including computer program products and implementing techniques for mixing liquid components. Quantities of two or more liquid components are transferred from pressurized source reservoirs to one or more destination locations by means of a fluid outlet that includes a dispense valve, and the two or more liquid components are mixed in the destination locations to create a plurality of fluid mixtures. Two or more dispensing technologies can be combined to provide for increased efficiency in the dispensing of high volume liquid components. The amounts of liquid components being dispensed can be monitored during the dispensing to provide feedback control of the dispensing.

主权项

1. A system for dispensing liquids, comprising:
a plurality of pressurizable source reservoirs, each of the pressurizable source reservoirs containing a liquid component and being operable to maintain an elevated pressure for forcing the corresponding liquid component to exit the source reservoir; one or more destination substrates having one or more destination locations for receiving liquid components to prepare one or more liquid mixtures; a conduit network comprising a plurality of inlets, each of the plurality of inlets being associated with one of the plurality of pressurizable source reservoirs, the conduit network defining a flow path from each of the plurality of inlets; a first fluid outlet for receiving liquid components through the flow path from each of the plurality of inlets, the first fluid outlet comprising a common dispense valve and being positionable to dispense the received liquid components through the common dispense valve into any of the one or more destination locations; and a control system programmed to control the first fluid outlet and the common dispense valve to position the first fluid outlet and activate the common dispense valve for dispensing liquid components at the one or more destination locations, the control system further programmed to meter quantities of the liquid components dispensed through the common dispense valve by controlling a dispense interval of the common dispense valve.