Service induced byproducts for localized drug delivery in orthopaedic implants

摘要

A composite material including ultra-high molecular weight polyethylene in conjunction with a biologically active agent is described. The biologically active agent can be, for example, an anti-osteolytic agent such as a bisphosphonate. The composite material can be utilized in forming implants such as total joint replacement implants. The biologically active agent can be released from the composite material either from the bulk or from wear particles released from the surface of the implant component during use. Upon release, the biologically active agent can carry out the intended function of the agent.

主权项

1. A joint replacement comprising a component, the component comprising an ultra-high molecular weight polyethylene composite, the ultra-high molecular weight polyethylene composite including a biologically active agent blended with the ultra-high molecular weight polyethylene such that the biologically active agent is distributed homogenously or heterogeneously throughout the component.