Compounds, compositions and methods for reducing toxicity and treating or preventing diseases

摘要

The present invention provides compounds of Formula (I), compositions comprising an effective amount of a compound of Formula (I), optionally with chemotherapeutic drugs such as a tubulin-binding drug, and methods of their use for reducing the toxicity of cytotoxic agents, treating or preventing cancer or a neuropathic disorder, inducing a chemoprotective phase II enzyme, DNA, or protein synthesis, enhancing the immune system, treating inflammation, improving and enhancing general health or well-being, and methods for making compounds of Formula (I).;

主权项

1. A compound of the Formula wherein: each R1 is independently —H; each R2 is independently —H, —C1-C6 alkyl, or —C(O)—C1-C6 alkyl, or both R2 groups combine to form —C(O)— or —C(Ra)(Ra)—, wherein each Ra is independently —H, —C1-C6 alkyl or phenyl; R3 is —H; and Z is —C1-C10 alkyl;or a pharmaceutically acceptable salt, solvate or hydrate thereof.