DEVICE AND METHOD FOR PRODUCING PHARMACEUTICALLY HIGHLY REFINED PARTICLES AND FOR COATING SAID PARTICLES IN MICROREACTORS

摘要

The invention relates to pharmaceutical active substance particles having small particle size, wherein said particles are produced by combining a solvent-non-solvent precipitate with an in-situ spray drying process. A pharmaceutical active substance is dispersed in a water-soluble solvent, in particular ethanol, and heated in an infeed line under pressure to above the boiling point of the solvent until solubilization. Said solution collides as a fine fluid jet with a fine water jet in a gas-permeated microreactor, and the fine mist so arising is thereby very rapidly vaporized. The organic solvent vaporizes first, then the water. The water can comprise surface modifiers.