SYNTHESIS OF BORONIC ESTER AND ACID COMPOUNDS

摘要

A process for the preparation of a cyclic trimeric boronic acid anhydride of formula (XXIV): (see formula XXIV) wherein a compound of formula (XIV): (see formula XIV) or a boronic acid anhydride thereof, is extracted into dichloromethane, the solvent is exchanged to ethyl acetate, and the compound of formula (XIV), or a boronic acid anhydride thereof, is crystallized by addition of hexane or heptane. A process for a large-scale process for forming a compound of formula (XIV) or a boronic acid anhydride thereof.