METHOD FOR PREDICTION OF OVERALL SURVIVAL IN PATIENTS SUFFERING FROM LIVER METASTASES OF COLORECTAL CANCER FOLLOWING HEPATIC RESECTION

摘要

FIELD: medicine.SUBSTANCE: method involves examining the tumour liver biopsy material by immunohistochemistry and detecting if any lymphocytic infiltration is observed in the liver metastasis stroma in three visual fields of a microscope and measuring an area thereof. The visual fields are specified by the maximum immunohistochemical reaction of each section of the liver biopsy material; the presence of lymphocytic infiltration and the area thereof is used to predict the overall survival. The presence of lymphocytic infiltration and the area thereof of 50% and more of the tumour stroma in each of the three visual fields, the patient is referred to a group with a favourable prognosis (the three or more years survival after hepatic resection); the absence of the lymphocytic infiltration or its area making less than 10% of the tumour stroma in each of the three visual fields, the patient is referred to a group of the unfavourable prognosis (the survival of less than two years).EFFECT: using the method provides the more accurate prediction of the overall survival following hepatic resection for the metastatic colorectal cancer and makes it possible to predict the patient's total survival.1 tbl, 4 ex