| 摘要 |
FIELD: medicine.SUBSTANCE: method involves detecting a threatening miscarriage and a carrier state of the polymorphism in the gene of folate metabolism, as well as a CD54lymphocyte ratio, lactoferrin and ?-subunit of human chorionic gonadotropin (?-HCG) levels in venous blood of a pregnant woman from the onset of pregnancy to the end of the first trimester. That is followed by calculating a prognostic index (PI) by formula: PI=0.7199X+1.2552X-0.00653X-0.0009X+0.0722X+1.1277, wherein Xis the threatening miscarriage, yes/no (1/0); Xis the polymorphism in the gene of folate metabolism, yes/no (1/0); Xis the CD54lymphocyte ratio, %; Xis the lactoferrin level, ng/ml; Xis the concentration of the free ?-subunit of human chorionic gonadotropin (?-HCG), ng/ml. If PI<0, the gestational complications are predicted, while PI>0 enables stating a low risk of pathological conditions accompanying pregnancy. A sensitivity of the presented method makes 81.2%, its specificity is 85.1%. The method effectiveness is 83.2%.EFFECT: method is minimally invasive, enables identifying a risk group of the gestational complications early that makes it possible to implement preventive measures aiming at preventing the pathological course of the pregnancy.5 ex |
