| 摘要 |
FIELD: medicine.SUBSTANCE: invention relates to medicine. Described is a method of synthesising conjugates of glycoseaminoglycanes (GAG) with biologically active molecules of different origin, which include low molecular compounds and macromolecules. In particular the invention relates to conjugation of hyaluronic acid (HA) and its derivatives with polypeptides and proteins with the biological function, such as, for instance, interferons, erythropoietins, growth factors, insulin, cytokines, antibodies and hormones.EFFECT: invention makes it possible to separate intermediate compounds, obtained by the partial or full interaction of GAG with protected aminoaldehydes in the method of conjugation Conjugates are able to increase the efficiency of a conjugated medication and support it in the course of time.25 cl, 13 dwg, 15 ex |
