USE OF CD83 IN COMBINATION THERAPY

摘要

PROBLEM TO BE SOLVED: To provide an improved method for suppressing and/or preventing an undesired immune response, including use of CD83.SOLUTION: CD83 is simultaneously administered to a subject together with at least one of other immunosuppressive compounds. A method for producing a tolerance- inducible dendritic cell and a regulatory T cell is also provided. These cells can be used in vitro for producing a further cell for therapeutic purpose and can be used in vivo for suppressing and/or preventing an undesired immune response. They can be used for preventing an autoimmune disease or for reducing its seriousness, and also can be used for inducing tolerance-inductivity into at least one therapeutic composition such as therapeutic protein or transplanted tissue.