| 发明名称 |
PYRAZOLO[1,5a]PYRIMIDINE DERIVATIVES AS IRAK4 MODULATORS |
| 摘要 |
Compounds of the formula I or II:;;wherein X, m, Ar, R1 and R2 are as defined herein. The subject compounds are useful for treatment of IRAK-mediated conditions. |
| 申请公布号 |
US2014303149(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201414243074 |
申请日期 |
2014.04.02 |
| 申请人 |
Hoffmann-La Roche Inc. |
发明人 |
Arora Nidhi;Chen Shaoqing;Hermann Johannes Cornelius;Kuglstatter Andreas;Labadie Sharada Shenvi;Lin Clara Jeou Jen;Lucas Matthew C.;Moore Amy Geraldine;Papp Eva;Talamas Francisco Xavier;Wanner Jutta;Zhai Yansheng |
| 分类号 |
C07D495/04;C07D487/04 |
主分类号 |
C07D495/04 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound of formula I or formula II:or a pharmaceutically acceptable salt thereof,wherein:
X is N or CH m is 1 or 2; Ar is:
optionally substituted aryl; oroptionally substituted heteroaryl; R1 is:
hydrogen;C1-6alkyl;C1-6alkoxy;hydroxy;hydroxy-C1-6alkyl;C1-6alkyl-amino;amino-C1-6alkyl;amino-C1-6alkyl-amino;hydroxy-C1-6alkylaminoC3-6cycloalkylamino;amino-C3-6cycloalkylamino;amino-C3-6heterocycloalkylamino;aminocarbonyl;halo;hydroxy-C1-6alkyl; orhydroxy-C1-6alkoxy; and R2 is:
hydrogen; orC1-6alkyl. |
| 地址 |
Nutley NJ US |
