GPR15-MEDIATED HOMING AND USES THEREOF

摘要

The present invention is directed to in vitro methods for promoting expression of G-protein coupled receptor 15 (GPR15) on T cells, GPR15+ enriched populations of T cells generated using these methods and compositions thereof, as well as methods of using these T cell populations for therapeutic purposes. Use of these GPR15+ enriched populations of T cells for treating conditions/diseases of the large intestine and in the preparation of a medicament for treating conditions/diseases of the large intestine is also envisioned.