COMPOSITIONS AND METHODS FOR DENTAL TISSUE REGENERATION

摘要

Provided is a method for regenerating dental tissue, which can include contacting a scaffold containing Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF, with a dental tissue so as to promote odontoblastic differentiation of a progenitor cell, promote progenitor cell migration into the dental tissue, or regenerate the dental tissue. Also provided is a composition for regeneration of dental tissue, which can include a scaffold and Wnt3a and BMP-7, and optionally VEGF, bFGF, or NGF.

主权项

1. A composition for regenerating dental tissue comprising:
a matrix or scaffold comprising a hydrogel; and a therapeutically effective amount of Wnt3a polypeptide; and a therapeutically effective amount of bone morphogenetic protein 7 (BMP-7); and optionally, a therapeutically effective amount of vascular endothelial growth factor (VEGF), basic fibroblast growth factor (bFGF), or nerve growth factor (NGF); wherein
the composition does not comprise a living cell, andmatrix or scaffold comprises Wnt3a and BMP-7 and, optionally, VEGF, bFGF, or NGF.