| 发明名称 |
FULLY HUMAN, ANTI-MESOTHELIN SPECIFIC CHIMERIC IMMUNE RECEPTOR FOR REDIRECTED MESOTHELIN-EXPRESSING CELL TARGETING |
| 摘要 |
The present invention relates to compositions and methods for treating diseases, disorders or conditions associated with dysregulated expression of mesothelin. In one embodiment, the invention relates to a fully human chimeric antigen receptor (CAR) wherein the CAR is able to target mesothelin. |
| 申请公布号 |
US2014301993(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201214354171 |
申请日期 |
2012.10.26 |
| 申请人 |
THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA |
发明人 |
Powell, JR. Daniel J.;Scholler Nathalie |
| 分类号 |
A61K35/14;C07K16/28 |
主分类号 |
A61K35/14 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated nucleic acid sequence encoding a chimeric antigen receptor (CAR), wherein the isolated nucleic acid sequence comprises the sequence of a human mesothelin binding domain and the sequence of a CD3 zeta signaling domain. |
| 地址 |
PHILADELPHIA PA US |
