ANTI-ARENAVIRAL COMPOUNDS

摘要

Described herein are 4-methyl-piperazine-1-carbothioic acid amide derivatives and analogs, as well as compositions containing the same, for the treatment or prophylaxis of viral infections and diseases associated therewith, particularly those viral infections and associated diseases caused by hemorrhagic fever viruses, such as Arenaviruses.

主权项

1. A pharmaceutical composition comprising a pharmaceutically acceptable carrier and a pharmaceutically effective amount of a compound
selected from the group consisting of: N1,N4-diphenylpiperazine-1,4-dicarbothioamide; N-(4-chlorophenyl)-4-methyl-piperazine-1-carbothioamide; N-(3,4-dichlorophenyl)-4-phenyl-piperazine-1-carbothioamide; N-(3-chlorophenyl)-4-methyl-piperazine-1-carbothioamide; N-(2,4-dichlorophenyl)-4-methyl-piperazine-1-carbothioamide; 4-methyl-N-(m-tolyl)piperazine-1-carbothioamide; N-(3,4-dichlorophenyl)piperidine-1-carbothioamide; N-(3,4-dichlorophenyl)morpholine-4-carbothioamide; 4-methyl-N-[3-(trifluoromethyl)phenyl]piperazine-1-carbothioamide; ethyl 4-[(3,4-dichlorophenyl)carbamothioyl]piperazine-1-carboxylate; N-(3,4-dichlorophenyl)-4-(2-pyridyl)piperazine-1-carbothioamide; N-(3-methoxyphenyl)-4-methyl-piperazine-1-carbothioamide; N-(3,5-dimethylphenyl)-4-methyl-piperazine-1-carbothioamide; N-(2,4-dimethylphenyl)-4-methyl-piperazine-1-carbothioamide; 1-tert-butyl-3-(3,4-dichlorophenyl)thiourea; N-(4-chloro-2,5-dimethoxy-phenyl)-4-methyl-piperazine-1-carbothioamide; N-(4-anilinophenyl)-4-methyl-piperazine-1-carbothioamide; 1-(3,4-dichlorophenyl)-3-(4-ethylphenyl)thiourea; 1-(3,4-dichlorophenyl)-3-(m-tolyl)thiourea; N-(3,4-dichlorophenyl)-4-pyrimidin-2-yl-piperazine-1-carbothioamide; N-(3-chloro-4-fluoro-phenyl)-4-methylsulfonyl-piperazine-1-carbothioamide; N-(3-chloro-4-methyl-phenyl)-4-ethyl-piperazine-1-carbothioamide; 1-(3-chloro-4-fluoro-phenyl)-3-[4-(diethylamino)phenyl]thiourea and 1-[(3-chlorophenyl)methyl]-1-(2-morpholinoethyl)-3-phenyl-thiourea.