| 摘要 |
Methods for predicting NF-kappaB (NF-kB) activity in a tumor, and more particularly to methods for predicting survival and therapeutic outcome, and selecting therapy in subjects with tumors, e.g., adenocarcinomas, e.g., lung adenocarcinomas and melanomas. |
| 主权项 |
1. A method of predicting NF-kB transcriptional activity in a tumor, the method comprising:
determining gene expression levels for guanylate binding protein 1, interferon-inducible (GBP1); proteasome (prosome, macropain) subunit, beta type, 9 (large multifunctional peptidase 2) (PSMB9); interferon regulatory factor 1 (IRF1); transporter 1, ATP-binding cassette, sub-family B (MDR/TAP) (TAP1); tumor necrosis factor, alpha-induced protein 3 (TNFAIP3); chemokine (C-C motif) ligand 5 (CCL5); proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctional peptidase 7) (PSMB8); interleukin 32 (IL32); SH2B adaptor protein 3 (SH2B3); and nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon (NFKBIE) in a sample comprising cells from the tumor; and comparing the gene expression levels to reference levels; optionally assigning a score to the tumor based on the comparison of the gene expression levels in the tumor to the reference levels; wherein the presence of gene expression levels above the reference levels, or a score above a threshold score, indicates that the tumor has high levels of NF-kB activity, and the presence of gene expression levels below the reference levels, or a score below the threshold score indicates that the tumor has low levels of NF-kB activity. |
