| 发明名称 |
TARGETED DISRUPTION OF T CELL RECEPTOR GENES USING ENGINEERED ZINC FINGER PROTEIN NUCLEASES |
| 摘要 |
Disclosed herein are methods and compositions for modifying TCR genes, using nucleases (zinc finger nucleases or TAL nucleases) to modify TCR genes. |
| 申请公布号 |
US2014301990(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201414221074 |
申请日期 |
2014.03.20 |
| 申请人 |
Ospedale San Raffaele srl ;Sangamo BioSciences, Inc. |
发明人 |
Gregory Philip D.;Holmes Michael C.;Paschon David;Zhang Lei;Bonini Maria Chiara;Genovese Pietro;Magnani Zulma;Mastaglio Sara;Naldini Luigi |
| 分类号 |
A61K35/26;C12N15/87 |
主分类号 |
A61K35/26 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated T-lymphocyte comprising a stably integrated exogenous sequence encoding a T-cell receptor (TCR), wherein at least one endogenous TCR gene within the cell is partially or completely inactivated by a zinc finger nuclease or a TALEN the TALEN comprising a TAL-effector DNA-binding domain and a cleavage domain, and further wherein the TAL-effector DNA-binding domain comprises a C-terminal truncation as compared to a wild-type TAL-effector DNA-domain. |
| 地址 |
Milan IT |
