发明名称 |
NOVEL N-(2,3-DIHYDRO-1H-PYRROLO[2,3-B]PYRIDIN-5-YL)-4- QUINAZOLINAMINE AND N-(2,3-DIHYDRO-1H-INDOL-5-YL)-4- QUINAZOLINAMINE DERIVATIVES AS PERK INHIBITORS |
摘要 |
The present invention relates to N-(2,3-dihydro-1H-pyrrolo[2,3-b)]pyridin-5-yl)-4-quinazolinamine and N-(2.3-dihydro-1H-indol-5-yl)-4-quinazolinamine derivatives of Formula (I) wherein R1, R2, R3, R4, R5, R6 and A have the meaning defined in the claims. The compounds according to the present invention are useful as inhibitors of PERK. The invention further relates to processes for preparing such compounds, pharmaceutical compositions comprising said compounds as an active ingredient as well as the use of said compounds as a medicament. |
申请公布号 |
CA2901267(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
CA20142901267 |
申请日期 |
2014.03.31 |
申请人 |
JANSSEN PHARMACEUTICA NV |
发明人 |
STANSFIELD, IAN;LIGNY, YANNICK AIME EDDY;AMBLARD, NATHALIE CLAUDIE ISABELLE;VERSELE, MATTHIAS LUC AIME |
分类号 |
C07D403/12;A61K31/517;A61P35/00;C07D403/14;C07D405/14;C07D409/14;C07D413/14;C07D471/04 |
主分类号 |
C07D403/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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