| 发明名称 |
MANUFACTURE OF VACCINES THAT CONTAIN BOTH HEPATITIS B VIRUS SURFACE ANTIGEN AND SURFACTANT |
| 摘要 |
When preparing HBsAg for use in a combination vaccine, it is known to add a non-ionic detergent after the HBsAg has been purified. Adding detergents after purification of HBsAg is not optimal, however, as it requires a separate processing step during manufacture. Thus the invention uses them during HBsAg purification. |
| 申请公布号 |
US2014302087(A1) |
申请公布日期 |
2014.10.09 |
| 申请号 |
US201414310273 |
申请日期 |
2014.06.20 |
| 申请人 |
Novartis Vaccines and Diagnostics, SRL |
发明人 |
CONTORNI Mario |
| 分类号 |
A61K39/39;A61K39/05;A61K39/13;A61K39/02;A61K39/102;A61K39/095;A61K39/29;A61K39/08 |
主分类号 |
A61K39/39 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A combination vaccine, wherein the vaccine comprises: (i) a non-ionic surfactant, (ii) a purified, recombinant hepatitis B virus (HBV) surface antigen (HBsAg) adsorbed onto an aluminium phosphate adjuvant, and (iii) an antigen from at least one non-HBV pathogen, wherein the non-ionic surfactant is present at <50 μg for every 100 μg of HBsAg. |
| 地址 |
Siena IT |
