发明名称 |
PYRROLOBENZODIAZEPINES AND TARGETED CONJUGATES |
摘要 |
This invention relates to pyrrolobenzodiazepines (PBDs), in particular pyrrolobenzodiazepine dimers having a C2-C3 double bond and an aryl group at the C2 position in each monomer unit, and their inclusion in targeted conjugates. The differing substituent groups may offer advantages in the preparation and use of the compounds, particularly in their biological properties and the synthesis of conjugates, and the biological properties of these conjugates. |
申请公布号 |
US2014302066(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
US201214351172 |
申请日期 |
2012.10.12 |
申请人 |
SEATTLE GENETICS, INC. ;SPIROGEN SÀRL |
发明人 |
Jeffrey Scott;Burke Patrick;Howard Philip Wilson |
分类号 |
A61K47/48;A61K31/5517;C07D487/04 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Bothell WA US |