TRICYCLIC QUINOLONE DERIVATIVE AND PREPARATION METHOD AND USE THEREOF

摘要

Disclose in the invention are a tricyclic quinolone derivative having a novel structure with a peripheral group at position C10 being substituted by non-alkaline substituents or salts and hydrates thereof. Such compounds have been proven to have anti-microbial activity against a variety of sensitive strains and drug-resistant strains through activity assays made on various strains, and can be used for treating infectious diseases caused by gram-negative and gram-positive bacteria, in particular being suitable for treating diseases caused by methicillin-resistant Staphylococcus aureus (MRSA) and Pseudomonas aeruginosa infections.