| 摘要 |
N-acyldipeptide derivatives are described. Compositions comprising the N-acyldipeptide derivatives are therapeutically effective for topical or systemic administration to alleviate or improve conditions, disorders, diseases, symptoms or syndromes associated with a tumor, cancer, immune, nervous, vascular, musculoskeletal or cutaneous system, or other tissue or system in a subject. |
| 主权项 |
1. A composition for topical or systemic administration to a mammal comprising a pharmaceutically or cosmetically acceptable carrier and a therapeutically effective amount of a dipeptide derivative having the following generic Formula (I):
R1-AAB-AAC-R2 Formula (I) or an isomer, free acid, base, salt, lactone, amide, hydrazide, or ester thereof, wherein R1 is an acyl radical having up to 19 carbon atoms; AAB is an amino terminal amino acid residue selected from any amino acid; AAC is a carboxyl terminal amino acid residue selected from any amino acid; R2 is OR3, NHR4 or NHNHR5; R3 is H, an alkyl, aralkyl or aryl radical having up to 19 carbon atoms; R4 or R5 is independently H, OH, an alkyl, aralkyl, aryl or acyl radical having up to 19 carbon atoms; a side chain of each of AAB and AAC optionally and independently has an extra functional radical selected from the group consisting of OH, SH, NHCONH2, NHC(═NH)NH2, NH2, COOH, CONH2, imidazolyl, pyrrolidinyl and indolyl; and the H or OH of the extra functional radical is optionally substituted by NH2, an acyl, alkyl, aralkyl, or aryl radical having up to 19 carbon atoms. |
