发明名称 |
Compositions, Methods, and Kits for Identifying Candidate Molecules from Encoded Chemical Libraries |
摘要 |
The subject matter relates to relates to a one-bead-one-sequence composition, a library of tagged chemicals comprising a plurality of one-bead-one-sequence compositions, a method for identifying a candidate molecule from a library of tagged chemicals, and a composition produced by a process, all as described herein. |
申请公布号 |
US2014303009(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
US201414259380 |
申请日期 |
2014.04.23 |
申请人 |
Wake Forest University |
发明人 |
Guthold Martin;Macosko Jed C. |
分类号 |
C12N15/10 |
主分类号 |
C12N15/10 |
代理机构 |
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代理人 |
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主权项 |
1. A one-bead-one-sequence composition comprising:
a) a microscopic bead; b) a plurality of identical copies of a single-species, sequenceable molecule, each operably connected to said microscopic bead; and c) a tag sequence which is complementary to, and is hybridized to, said sequenceable molecule, d) a candidate chemical operably connected to said tag sequence, wherein said sequenceable molecule is a unique identifier for its complementary tag sequence, and wherein said tag sequence is a unique identifier for its connected candidate chemical. |
地址 |
Winston-Salem NC US |