发明名称 |
DERIVATIZED 3-STYRYL-CEPHALOSPORINS |
摘要 |
<p>Broad spectrum beta-lactamase inhibitors. Certain inhibitors also exhibit potent antibiotic activity in addition to beta-lactamase inhibition. Compounds of the invention are designed such that on cleavage of the beta-lactam ring reactive moieties are generated which can inactivate beta-lactamase. Also provided are methods of making betalactamase inhibitors and beta-lactam antibiotics exhibiting such inhibition. Additionally provided are pharmaceutical compositions for treatment or prevention of bacterial infections and methods of treatment of such infections.</p> |
申请公布号 |
WO2014165126(A2) |
申请公布日期 |
2014.10.09 |
申请号 |
WO2014US24503 |
申请日期 |
2014.03.12 |
申请人 |
SOPHARMIA, INC. |
发明人 |
SUTTON, LARRY D.;YU, SOPHIA |
分类号 |
A61K31/545;C07D501/20 |
主分类号 |
A61K31/545 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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