| 摘要 |
<p>The invention relates to the field of biotechnology and medicine, and more particularly to novel sequence variants of a chimeric peptide comprising a functional fragment and a transporting sequence, wherein the functional fragment comprises an amino acid sequence selected from the group SEQ ID NO: 1 - SEQ ID NO: 17, as well as homologous sequences thereof with at least 60% sequence identity thereto; the invention further relates to a functional peptide with anti-proliferation activity represented by an amino acid sequence selected from the group SEQ ID NO: 1 - SEQ ID NO: 17, as well as homologous sequences thereof with at least 60% sequence identity thereto. The invention also relates to the use of the above-mentioned chimeric peptide for treating oncological diseases, as well as to a pharmaceutical composition having anti-proliferation activity and a method for treating oncological diseases, which comprises administration of said chimeric peptide to a mammal in need of such treatment. The invention makes it possible to develop a drug preparation which effectively penetrates target cells and has a high cytostatic and cytotoxic effect towards tumour cells.</p> |
