发明名称 |
CONTROLLED TRANSLOCATION OF MACROMOLECULES EMPLOYING A FUNNEL NANOPORE STRUCTURE AND A GEL |
摘要 |
<p>A system of controlled translocation of macromolecules by gel electrophesis employs a funnel nanopore structure. A graphene portion is attached to a porous material layer including funnel-shaped pores such that the graphene portion blocks the side of the porous material layer having openings for smaller pores. A pair of electrical contacts is formed on the graphene portion. A dielectric material layer may be deposited to hold the graphene portion in place. A nanoscale hole is formed through the dielectric material layer and the graphene portion to provide a smallest opening in a funnel nanopore structure. The funnel nanopore structure is placed within a capsule configured for gel electrophoresis. A linear chain of molecules can pass through a funnel-shaped pore and the nanoscale hole during the gel electrophoresis. A graphene nanopore detector allows measurement of blockage current for sufficient resolution of base pairs in DNA's.</p> |
申请公布号 |
WO2014165318(A2) |
申请公布日期 |
2014.10.09 |
申请号 |
WO2014US30991 |
申请日期 |
2014.03.18 |
申请人 |
INTERNATIONAL BUSINESS MACHINES CORPORATION |
发明人 |
WALKER, GEORGE F. |
分类号 |
G01N27/447 |
主分类号 |
G01N27/447 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|