发明名称 |
FC REGION VARIANT |
摘要 |
It is found that a polypeptide, which contains an antibody Fc region variant that comprises an amino acid sequence composed of a combination of an alteration of an amino acid residue located at position-238 as numbered in accordance with the EU index and an alteration of another specific amino acid residue, has a reduced binding activity to all of active Fc?R's, especially to Fc?RIIa (type R), compared with polypeptides each containing a naturally occurring IgG Fc region, while maintaining the binding activity thereof to Fc?RIIb. |
申请公布号 |
CA2908350(A1) |
申请公布日期 |
2014.10.09 |
申请号 |
CA20142908350 |
申请日期 |
2014.04.02 |
申请人 |
CHUGAL SEIYAKU KABUSHIKI KAISHA |
发明人 |
MIMOTO, FUTA;KATADA, HITOSHI;IGAWA, TOMOYUKI |
分类号 |
C07K16/00;A61K39/395;A61P9/00;A61P31/12;A61P35/00;A61P37/00;A61P37/06;C07K19/00;C12N15/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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