| 摘要 |
A N-benzylaniline derivative and uses thereof. The derivative is a compound represented by formula I or a pharmaceutically acceptable salt thereof. The compound protects against cerebral ischemia/reperfusion injury and has analgesic action for chronic pathologic pain, and may be used to treat cerebral apoplexy, neuropathic pain, and inflammatory pain. Moreover, because of the unique mechanism of action of the compound, the compound can be used to treat epilepsy, affective disorder, and neurodegenerative diseases.; |
| 主权项 |
1. An N-benzylaniline derivative having the structure of general formula (I),wherein,
R1 is hydroxyl, C1-C6 alkoxy or —OCOR11; R2, R3, R5, R6, R9 or R10 is each independently hydrogen, halogen or trifluoromethyl; R4 is halogen or trifluoromethyl; R7 or R8 is each independently —COR12, hydroxyl, C1-C6 alkoxy, —OCH2COR12, —OCOR11 or —OCH2COB; X is hydrogen or C1-C6 alkyl; Y is hydrogen, C1-C6 alkyl, —CH2COR13 or —COR13; R11 is C1-C6 alkyl or B; R12 is C1-C6 alkyl, hydroxyl, C1-C6 alkoxy or B; R13 is C1-C6 alkyl, C1-C6 alkoxy or B; B is wherein at least one of R7, R8 and Y contains B group, or X and Y are not both hydrogen, or a pharmaceutically acceptable salt thereof. |
