COMPOSITIONS COMPRISING AN ARYL PYRAZOLE AND A SUBSTITUTED IMIDAZOLE, METHODS AND USES THEREOF

摘要

This invention relates to compositions for combating parasites in animals, comprising 1-arylpyrazole compounds in combination with substituted imidazole compounds. This invention also provides for an improved methods for eradicating, controlling, and preventing parasite infestation in an animal comprising administering the compositions of the invention to an animal in need thereof.

主权项

1. A veterinary formulation for treating or preventing a parasitic infestation in an animal comprising:
(a) a 1-aryl-5-alkyl or 5-haloalkylpyrazole of formula (IA) or a veterinarily acceptable salt thereof,wherein:
R2a is —S(O)mR11a; R3a is methyl, ethyl or C1-C4 haloalkyl; R4a is halogen; R6a is C1-C4 alkyl or haloalkyl; R13a is halogen; R11a is C1-C4 haloalkyl; and m is 0, 1 or 2; (b) a substituted imidazole compound of formula (II),wherein X1, X2, X3, X4, X5, X6, X7 and X8 are defined as in Table 1;
(c) a veterinarily acceptable carrier; and (d) optionally a crystallization inhibitor.