| 主权项 |
1. An immunoassay for detecting clozapine in a sample comprising providing a mixture of a) said sample, b) an antibody selectively reactive with clozapine and not substantially cross-reactive with N-desmethylclozapine and clozapine-N-oxide, and c) a conjugate of a carrier having either a reactive thiol or amino group with a compound of the formula: wherein B is: —(C═O)—, —(C═O)—NH—, —(C═O)—O—, —CH2—; Y is an organic spacing group; X is a terminal functional group capable of binding to a polyamine polymer; and p is an integer from 0 to 1;or salts thereof;causing the clozapine in the sample and said conjugate in said mixture to bind with said antibody and thereafter measuring the amount of said conjugate in said mixture which is bound or unbound to said antibody whereby the presence of clozapine in the sample can be determined. |
