Modified Effector Cell (or Chimeric Receptor) for Treating Disialoganglioside GD2-Expressing Neoplasia

摘要

A modified effector cell includes a non-reversibly produced vector-encoded anti-GD2-BB-ζ chimeric receptor for use in disialoganglioside GD2-expressing neoplasia, which is inserted in the cell, to obtain an effector cell that stably produces the anti-GD2-BB-ζ chimeric receptor, the chimeric receptor having two distinct mutually fused portions, i.e. an intra-cytoplasmic portion and an extra-cytoplasmic portion.

主权项

1. A modified effector cell or chimeric receptor for treating disialoganglioside GD2-expressing neoplasia, comprising:
a cytoplasm with a nucleus therein, which is enclosed in a plasma membrane; and a chimeric receptor, wherein said chimeric receptor comprises an intracytoplasmic portion and an extracytoplasmic portion which is fused to said intracytoplasmic portion.