Method of Treating Mixed Lineage Leukemia Gene-Rearranged Acute Lymphoblastic Leukemias

摘要

The present invention relates to a method of treating a warm-blooded animal, especially a human, having Mixed Lineage Leukemia (MLL rearranged ALL) comprising administering to said animal a therapeutically effective amount of a staurosporine derivative, especially PKC412 or a pharmaceutically acceptable salt thereof, alone or in combination with further therapeutic measures, for example, those defined herein; to the use of a staurosporine derivative for the preparation of a medicament for the treatment of MLL rearranged ALL; and to a commercial package comprising a staurosporine derivative together with instructions for its use in the treatment of MLL rearranged ALL.

主权项

1. A method of treating mixed lineage leukemia gene rearranged acute lymphoblastic leukemia (MLL rearranged ALL) in a human patient in need thereof comprising administering a therapeutically effective amount in the range from 100 mg/day to 1000 mg/day of PKC412, or a pharmaceutically acceptable salt thereof, to the human having MLL rearranged ALL.