| 主权项 |
1. A compound of Formula (A), or a pharmaceutically acceptable salt, N-oxide, solvate, or deuterated derivative thereof: wherein:
R1 and R2 are independently chosen from a hydrogen atom, a linear or branched C1-4 alkyl group, a linear or branched C1-4 hydroxyalkyl group, or a linear or branched C1-4 alkoxy group,R3 has formula: wherein:
R4 is chosen from a hydrogen atom, a hydroxy group, a C1-4 hydroxyalkyl group, a linear or branched C1-4 alkyl group, or a linear or branched C1-4 alkoxy group,R5 is chosen from a saturated or unsaturated C3-8 cycloalkyl group, a C5-6 aryl group, a 5- to 6-membered heteroaryl group containing at least one heteroatom chosen from N, S, or O, a (C1-4 alkyl)-(C5-6 aryl) group, a (C1-4 alkyl)-(C3-8 cycloalkyl) group, or a (C1-4 alkyl)-(5- to 6-membered heteroaryl group containing at least one heteroatom chosen from N, S, or O) group, which groups independently are unsubstituted or substituted with at least one Ra,R6 is chosen from a C5-6 aryl group, a 5- to 6-membered heteroaryl group containing at least one heteroatom chosen from N, S, or O, a saturated or unsaturated C3-8 cycloalkyl group, a linear or branched C1-8 alkyl group, a C2-8 alkenyl group, a C2-8 alkynyl group, a linear or branched C1-8 alkoxy group, a (C1-4 alkyl)-(C5-6 aryl) group, a (C1-4 alkyl)-(C3-8 cycloalkyl) group, or a (C1-4 alkyl)-(5- to 6-membered heteroaryl group containing at least one heteroatom chosen from N, S, O) group, which groups independently are unsubstituted or substituted with at least one Rb,Ra and Rb are independently chosen from a halogen atom, a hydroxy group, a C1-4 alkyl group, C1-4 alkoxy group, —SH, a C1-4 alkylthio group, a nitro group, a cyano group, —CO2R′, —NR′R″′, —C(O)NR′R″, —N(R′″)C(O)—R″, —N(R′″)—C(O)NR′R″, wherein R′, R″ and R′″ are independently chosen from a hydrogen atom or a C1-4 alkyl group, or R′ and R″ together with the nitrogen atom to which they are attached from a 3- to 6-membered heterocyclic ring,Q is chosen from a direct bond, —CH2—, —CH2—CH2—, —O—, —O—CH2—, —S—, —S—CH2—, —NH—, —NH—CH2—, or —CH═CH—,* is a point of attachment of R3 to the remainder of Formula (A),B is a moiety having a β2-adrenergic binding activity, andL is a covalent linker having Formula (L): wherein k1, k2, s1, s2, l2, t1, and t2 independently have a value of 0 or 1;
A1, A2, A3, A4 and A5 are independently chosen from a C1-10 alkylene group, a C2-10 alkenylene group, or a C2-10 alkynylene group, wherein the groups are unsubstituted or substituted with at least one substituent chosen from a halogen atom, a hydroxy group, a linear or branched C1-4 alkyl group, a linear or branched C1-4 alkoxy group, a C5-6 aryl group or a C3-7 cycloalkyl group,L1 and L2 independently are chosen from a direct bond, —O—, —NRc—, —S—, —S(O)—, —SO2—, —NRc(CO)—, —(CO)NRc—, —NRc(CO)(CH2)qO—, —O(CH2)q(CO)NR—, —O(CH2)qNRc—, —NRc(CH2)qO—, —NRc(CO)NRd—, —C(O)—, —C(O)O—, —OC(O)—, —S(O)2NRc—, —NRcS(O)2—, —NRcS(O)2NRd—, —C(O)NRcS(O)2— and —S(O)2NRcC(O)—, wherein Rc and Rd are independently chosen from a hydrogen atom or a linear or branched C1-4 alkyl group, and wherein q has a value of 0, 1 or 2,G and G1 independently are chosen from a direct bond, a C3-10 mono- or bicyclic cycloalkyl group, a C5-C14 mono- or bicyclic aryl group, a 3- to 14-membered saturated or unsaturated mono- or bicyclic heterocyclyl group comprising at least one heteroatom chosen from N, S or O, a 5- to 14-membered mono- or bicyclic heteroaryl group comprising at least one heteroatom chosen from N, S or O, or a bicyclic ring system comprising two monocyclic ring systems which are linked between each other by a covalent bond, whereinthe monocyclic ring systems are independently chosen from a C3-8 cycloalkyl group, a C5-6 aryl group, a 3- to 8-membered saturated or unsaturated heterocyclyl group comprising at least one heteroatom chosen from N, S or O, or a 5- to 6-membered heteroaryl group comprising at least one heteroatom chosen from N, S or O, wherein the cyclic groups independently are unsubstituted or substituted with at least one substituent chosen from a halogen atom, a C1-4 alkyl group, a C1-4 alkoxy group, a carboxy, group, a cyano group, a nitro group, a hydroxy group, an oxo group, a trifluoromethyl group or a trifluoromethoxy group. |
