RAGE AS A C1Q RECEPTOR, METHODS AND APPLICATIONS

摘要

A method of identifying a compound capable of reducing or increasing the amount of receptor for RAGE-Clq Binding comprising a) providing an amount of the compound to be tested; b) contacting the amount of the compound with Clq and RAGE; c) measuring the amount of RAGE-Clq binding in step b); d) comparing the amount of RAGE-Clq binding measured in step c) with the amount of RAGE-Clq binding measured under corresponding conditions in the absence of the compound; d) identifying the compound as capable of reducing or increasing the amount of RAGE-Clq binding. The present invention also provides a method of treating a subject suffering from a RAGE-related disorder comprising administering to the subject a therapeutically effective amount of a compound that is a modulator of the amount of RAGE-Clq binding so as to thereby treat the subject.