发明名称 |
INFLUENZA VIRUS VACCINES AND USES THEREOF |
摘要 |
The present disclosure provides influenza hemagglutinin stem domain polypeptides comprising (a) an influenza hemagglutinin HA1 domain that comprises an HA1 N-terminal stem segment, covalently linked by a linking sequence of 0-50 amino acid residues to an HA1 C-terminal stem segment, and (b) an influenza hemagglutinin HA2 domain, wherein on or more amino acids in the HA2 domain have been mutated. Also provided are nucleic acids encoding the polypeptides, compositions comprising the polypeptides and/or nucleic acid molecules, as well as methods of their use, in particular in the detection, prevention and/or treatment of influenza. |
申请公布号 |
EP2785372(A1) |
申请公布日期 |
2014.10.08 |
申请号 |
EP20120791759 |
申请日期 |
2012.11.27 |
申请人 |
CRUCELL HOLLAND B.V. |
发明人 |
MEIJBERG, JAN WILEM;IMPAGLIAZZO, ANTONIETTA;VOGELS, RONALD;FRIESEN, ROBERT HEINZ EDWARD;ALARD, PHILIPPE;LOVERIX, STEFAN;RADOSEVIC, KATARINA |
分类号 |
A61K39/12;C07K14/005 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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