| 发明名称 |
PREPARATION METHOD FOR INSULIN GLARGINE CRYSTAL |
| 摘要 |
<p>Disclosed is a method for preparing an insulin glargine (GlyA 21 -Arg B31 -Ary B32 - human insulin) crystal, comprising crystallizing the insulin glargine at pH 7.0-9.0 and in a crystallization solution containing a recombinant insulin glargine, an organic solvent of a 10-30% concentration by volume, a zinc compound, a phenol derivative, a salt and an organic acid.</p> |
| 申请公布号 |
EP2708550(A4) |
申请公布日期 |
2014.10.08 |
| 申请号 |
EP20120782610 |
申请日期 |
2012.04.19 |
| 申请人 |
GAN & LEE PHARMACEUTICALS |
发明人 |
WANG, DAMEI;LI, WENJIE;ZHANG, JINLEI |
| 分类号 |
C07K1/30;A61P3/10;B01D9/02;C07K14/62;C30B7/14;C30B29/58 |
主分类号 |
C07K1/30 |
| 代理机构 |
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