FUNCTIONAL ISOTYPE SWITCHING OF CHIMAERIC ANTIBODY CHAINS & CHIMAERIC ANIMALS EXPRESSING DIFFERENT IGH ISOTYPES

摘要

The invention discloses methods for the generation of chimaeric human-nonhuman antibodies and chimaeric antibody chains, antibodies and antibody chains so produced, and derivatives thereof including fully humanised antibodies; compositions comprising the disclosed antibodies, antibody chains and derivatives, as well as cells, non-human mammals and vectors, suitable for use in the disclosed methods.