发明名称 |
Antibodies against HER2 truncated variant CTF-611 |
摘要 |
The present invention relates to a method of diagnosis and therapy of cancers expressing the HER2 receptor. The invention provides antibodies or fragments thereof that recognise an epitope of the HER2 receptor truncated form CTF-61 1, said epitope being defined by a sequence included in SEQ ID NO: 2, and that are capable of discriminating between CTF-611 and CTF-616 (represented by SEQ ID NO:7), preferably additionally capable of discriminating between CTF-611 and CTF-613 (represented by SEQ ID NO:6) . The invention also provides a method of cancer diagnosis using the disclosed antibodies, which comprises the detection of the presence of the HER2 receptor truncated form consisting of the amino acid sequence SEQ ID NO: 1 in a patient sample. |
申请公布号 |
EP2330131(B1) |
申请公布日期 |
2014.10.08 |
申请号 |
EP20090380183 |
申请日期 |
2009.12.07 |
申请人 |
FUNDACIÓ PRIVADA INSTITUCIÓ CATALANA DE RECERCA IESTUDIS AVANÇANTS;FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÒGICA DE VALL-HEBRON |
发明人 |
ARRIBAS LÓPEZ, JOAQUÍN;PEDERSEN, KIM;ANGELLINI, PIER-DAVIDE;PARRA PALAU, JOSEP LLUÍS;BASELGA TORRES, JOSÉ |
分类号 |
C07K16/32;A61K39/395;A61P35/00;G01N33/53 |
主分类号 |
C07K16/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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